Splet13. okt. 2024 · The cation-independent mannose 6-phosphate receptor (CI-MPR) transports newly synthesized lysosomal enzymes from the trans -Golgi network (TGN) to endosomes, where the acidic pH causes release of the ligand, making the receptor free to recycle to the TGN ( Duncan and Kornfeld, 1988; Goda and Pfeffer, 1988 ). Splet10. jan. 2024 · Members of PRAF proteins are polarized in stomatal lineage cells in a BASL-dependent manner. Developmental defects of the praf mutants phenocopy those of the gnom mutants. GNOM is an activator of...
Mechanisms of Pharmacological Rescue of Trafficking-defective …
Splet30. mar. 2024 · The impaired KN1 trafficking in the mutants is verified by GFP observation in the M3 generation. The causal gene is determined by comparing genomes between mutants and non-mutants. First, the heterozygous mutants are isolated from the M2 family from which KN1 trafficking mutants were isolated. Splet31. jan. 2024 · The mechanism underlying this is unclear since LIMP2 does not appear to bind α-syn. Interestingly, this effect is not observed if mutant α-syn lacking amino acids 71–82 (i.e. fibrillation-incompetent α-syn) is overexpressed, again suggesting that the impairment in ER-to-lysosome trafficking of GCase is dependent on polymerization of α … general douglas macarthur nuclear bomb
Metaxins are core components of mitochondrial transport
Splet05. feb. 2024 · In a cct8 mutant background, the phenotype of a weak stm allele (stm-10) is enhanced, resulting in early meristem termination. This observation suggests that STM trafficking is required for proper formation and maintenance of the SAM, as cct8 hypomorphs have no obvious SAM phenotype. Splet26. avg. 2024 · Thus, multiple trafficking mutations can cotranslationally perturb NBD1-folding intermediates. As NBD1 folding involves a complex series of steps, it is perhaps not surprising that some mutations... Splet08. apr. 2024 · Bestrophin 1 (Best1) is a chloride channel that localises to the plasma membrane of retinal pigment epithelium (RPE) cells. Mutations in the BEST1 gene are associated with a group of untreatable inherited retinal dystrophies (IRDs) called bestrophinopathies, caused by protein instability and loss-of-function of the Best1 … general douglas macarthur role in world war 2